Unable to make progress with her ex-lesbian conversion path, a neurotic "All American" Jill tracks down her butch ex-girlfriend Jamie to prove to herself that she is no longer attracted to her. Strung along by guilt and desire, Jamie agrees to the preposterous plan of "dating" Jill so that Jill can close this chapter of her life and move forward with men.
Meanwhile, David and Lola compete for the affections of José, a sexually ambiguous and seductive man from Brazil, and they compare notes on their differing opinions of his sexuality. As complications arise with Jill and Jamie's relationship, Jill starts to see José as her ticket out. However, when the love triangles shift and realign, Jamie starts having her own identity crisis that she is ill-equipped to handle. A mix of over-the-top comedy, sharp wit, and pathos, Heterosexual Jill rides the edge of laughter and pain, desire and repression, and explores the complicated attachment to one's sense of self in the face of love.